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Contents in the Video:
00:00
The Checkmate 227 trial randomized patients to combined immunotherapy with nivolumab and ipilimumab versus chemotherapy frontline. The hypothesis was to postpone chemotherapy to second line only.
00:50
The primary endpoint of overall survival, analyzed only in PD-L1 positive patients, comparing ipilimumab/nivolumab vs chemotherapy, met statistical significance and clinically meaningful benefit. Superiority of immunotherapy was also met in response rate, progression free survival and duration of response.
02:41
In PD-L1 positive patients, there was a third comparator, nivolumab only. The exploratory analysis shows that nivolumab/ipilimumab was superior to nivolumab monotherapy.
03:19
In PD-L1 negative patients, ipilimumab/nivolumab performed as well as in PD-L1 positive patients.
04:08
Ipilimumab toxicity: In CheckMate 227, ipilimumab was given at low dose of 1mg/kg every 6 weeks, which was highly manageable. Although different in nature, toxicity was comparable in numbers between immunotherapy and chemotherapy.
04:59
The NICOLAS trial investigated concomitant application of immunotherapy and radiochemotherapy in early NSCLC and showed not only that this treatment was safe and feasible, but also encouraging PFS and OS results.
Interview with:
Prof. Solange Peters, MD, PhD
Interview by:
Dr. Birgit Beermann
Produced by:
Mag. Oliver Eberhardt
Dr. Birgit Beermann
30 Sept 2019Breakfast Brief

ESMO 2019: NSCLC – “We now have many frontline treatment options to discuss with patients”

Prof. Solange Peters, MD, PhD, CHUV Lausanne, puts the research she presented at ESMO 2019 in perspective by explaining the complex CheckMate 227 trial and giving an update on the NICOLAS trial.

References
  • Peters S et al. Nivolumab (NIVO) & low-dose ipilimumab (IPI) vs platinumdoublet chemotherapy (chemo) as first-line (1L) treatment (tx) for advanced non-small cell lung cancer (NSCLC): CheckMate 227 part 1 final analysis. #LBA4_PR
  • Peters S et al. Efficacy evaluation of concurrent nivolumab addition to a first-line, concurrent chemo-radiotherapy regimen in unresectable locally advanced NSCLC: Results from the European Thoracic Oncology Platform (ETOP 6-14) NICOLAS phase II trial. #1457PD

ESMO Congress 2019

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ESMO 2019: Immunotherapy drug combination offers chemo-free option for advanced NSCLC