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EAU 2017: Therapieerfolge beim Urothelkarzinom

EAU 2017: Therapieerfolge beim Urothelkarzinom

AM diesjährigen EAU konnten zunehmend auch Erfolge in der Therapie des metastasierten Urothelkarzinoms präsentiert und diskutiert werden. Weitere Highlights wie die Identifizierung von Resistenzen mit Biosensor-Chips oder Stammzellen gegen erektile Dysfunktion finden Sie hier auf einen Blick.(CliniCum urologie 1-2/17)

Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis.

Exercise for Men with Prostate Cancer: A Systematic Review and Meta-analysis.

<h3>Abstract</h3><div><h4>CONTEXT: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”CONTEXT”>Exercise could be beneficial for prostate cancer survivors. However, no systematic review across cancer stages and treatment types addressing potential benefits and harms exists to date.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To assess the effects of exercise on cancer-specific quality of life and adverse events / Weiterlesen →

Assessing the Optimal Timing for Early Salvage Radiation Therapy in Patients with Prostate-specific Antigen Rise After Radical Prostatectomy.

Assessing the Optimal Timing for Early Salvage Radiation Therapy in Patients with Prostate-specific Antigen Rise After Radical Prostatectomy.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Early salvage radiation therapy (eSRT) represents a treatment option for patients who experience a prostate-specific antigen (PSA) rise after radical prostatectomy (RP); however, the optimal PSA level for eSRT administration is still unclear.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To test the impact of PSA level / Weiterlesen →

Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages.

Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages.

<h3>Abstract</h3><div><p><abstracttext label=”UNLABELLED”>Benign prostatic hyperplasia (BPH) treatments have changed little over many years and do not directly address the underlying cause. Because BPH is characterised by uncontrolled cell growth, the chromosomal telomeres should be eroded in the reported absence or low levels of telomerase activity, but / Weiterlesen →

Pathologic Outcomes in Favorable-risk Prostate Cancer: Comparative Analysis of Men Electing Active Surveillance and Immediate Surgery.

Pathologic Outcomes in Favorable-risk Prostate Cancer: Comparative Analysis of Men Electing Active Surveillance and Immediate Surgery.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>It remains unclear whether men selecting active surveillance (AS) are at increased risk of unfavorable longer term outcomes as compared with men who undergo immediate treatment.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To compare adverse pathologic outcomes in men with favorable-risk prostate cancer who underwent delayed / Weiterlesen →

The Impact of Adding Taxanes to Gemcitabine and Platinum Chemotherapy for the First-Line Therapy of Advanced or Metastatic Urothelial Cancer: A Systematic Review and Meta-analysis.

The Impact of Adding Taxanes to Gemcitabine and Platinum Chemotherapy for the First-Line Therapy of Advanced or Metastatic Urothelial Cancer: A Systematic Review and Meta-analysis.

<h3>Abstract</h3><div><h4>CONTEXT: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”CONTEXT”>Gemcitabine/platinum chemotherapy is the most widely used first-line regimen for metastatic urothelial carcinoma, and the potential improvement of adding taxanes needs to be clarified.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To study the survival impact of taxane plus gemcitabine/platinum compared with gemcitabine/platinum alone as upfront therapy.</abstracttext></p><h4>EVIDENCE / Weiterlesen →

Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma.

Single-agent Taxane Versus Taxane-containing Combination Chemotherapy as Salvage Therapy for Advanced Urothelial Carcinoma.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Single-agent taxanes are commonly used as salvage systemic therapy for patients with advanced urothelial carcinoma (UC).</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To study the impact of combination chemotherapy delivering a taxane plus other chemotherapeutic agents compared with single-agent taxane as salvage therapy.</abstracttext></p><h4>DESIGN, SETTING, AND PARTICIPANTS: / Weiterlesen →

Nerve-sparing Surgery Technique, Not the Preservation of the Neurovascular Bundles, Leads to Improved Long-term Continence Rates After Radical Prostatectomy.

Nerve-sparing Surgery Technique, Not the Preservation of the Neurovascular Bundles, Leads to Improved Long-term Continence Rates After Radical Prostatectomy.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>The effect of preservation of neurovascular bundles (NVBs) during radical prostatectomy (RP) on continence remains controversial.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To analyze if the differing surgical techniques of nerve-sparing (NS) versus non-nerve-sparing (NNS) RP and not the preservation of the NVB itself may be / Weiterlesen →

Management of Challenging Urethro-ileal Anastomosis During Robotic Assisted Radical Cystectomy with Intracorporeal Neobladder Formation.

Management of Challenging Urethro-ileal Anastomosis During Robotic Assisted Radical Cystectomy with Intracorporeal Neobladder Formation.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Robotic assisted radical cystectomy (RARC) is increasingly being adopted, but intracorporeal neobladder formation remains a challenging procedure limited to selected centers. Common challenges with intracorporeal neobladder formation relate to fashioning a tension-free urethro-ileal anastomosis. In this paper, we describe a series of / Weiterlesen →

A Single-centre Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL).

A Single-centre Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL).

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RARC) are increasingly popular, but high-level evidence for these techniques remains lacking.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To compare the outcomes of patients undergoing open radical cystectomy (ORC), RARC, and LRC.</abstracttext></p><h4>DESIGN, SETTING, AND PARTICIPANTS: </h4><p><abstracttext nlmcategory=”METHODS” label=”DESIGN, / Weiterlesen →

Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy.

Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy.

<h3>Abstract</h3><div><h4>CONTEXT: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”CONTEXT”>The role of percutaneous renal tumour biopsy (RTB) remains controversial due to uncertainties regarding its diagnostic accuracy and safety.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>We performed a systematic review and meta-analysis to determine the safety and accuracy of percutaneous RTB for the diagnosis of malignancy, / Weiterlesen →

Clinical Utility of Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens.

Clinical Utility of Quantitative Gleason Grading in Prostate Biopsies and Prostatectomy Specimens.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Gleason grading is the strongest prognostic parameter in prostate cancer. Gleason grading is categorized as Gleason ≤6, 3+4, 4+3, 8, and 9-10, but there is variability within these subgroups. For example, Gleason 4 components may range from 5-45% in a Gleason 3+4=7 / Weiterlesen →

Acute Kidney Injury after Partial Nephrectomy: Role of Parenchymal Mass Reduction and Ischemia and Impact on Subsequent Functional Recovery.

Acute Kidney Injury after Partial Nephrectomy: Role of Parenchymal Mass Reduction and Ischemia and Impact on Subsequent Functional Recovery.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Acute increase of serum creatinine (SCr) after partial nephrectomy (PN) is primarily due to parenchymal mass reduction or ischemia; however, only ischemia can impact subsequent functional recovery.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>We evaluate etiologies of acute kidney injury (AKI) after PN and their prognostic / Weiterlesen →

Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND).

Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND).

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>Intermittent androgen deprivation (IAD) has received increasing attention; however, the current literature is still limited, especially in nonmetastatic prostate cancer (PCa), and the relative efficacy and safety benefits of IAD versus continuous androgen deprivation (CAD) remain unclear.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To add to / Weiterlesen →

Addition of Docetaxel to Androgen Deprivation Therapy for Patients with Hormone-sensitive Metastatic Prostate Cancer: A Systematic Review and Meta-analysis.

Addition of Docetaxel to Androgen Deprivation Therapy for Patients with Hormone-sensitive Metastatic Prostate Cancer: A Systematic Review and Meta-analysis.

<h3>Abstract</h3><div><h4>CONTEXT: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”CONTEXT”>Several randomized clinical trials (RCTs) have recently tested the early addition of docetaxel to androgen deprivation therapy (ADT) in hormone-sensitive metastatic prostate cancer (PCa).</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To perform a systematic review and meta-analysis of RCTs evaluating the combination of docetaxel and ADT / Weiterlesen →

The Surgical Learning Curve for One-stage Anterior Urethroplasty: A Prospective Single-surgeon Study.

The Surgical Learning Curve for One-stage Anterior Urethroplasty: A Prospective Single-surgeon Study.

<h3>Abstract</h3><div><h4>BACKGROUND: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”BACKGROUND”>The learning process for one-stage anterior urethroplasty has never been addressed before.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>To evaluate the surgical learning curve for one-stage anterior urethroplasty.</abstracttext></p><h4>DESIGN, SETTING, AND PARTICIPANTS: </h4><p><abstracttext nlmcategory=”METHODS” label=”DESIGN, SETTING, AND PARTICIPANTS”>Data from 641 consecutive patients treated with one-stage urethroplasty for / Weiterlesen →

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer.

<h3>Abstract</h3><div><h4>CONTEXT: </h4><p><abstracttext nlmcategory=”BACKGROUND” label=”CONTEXT”>Renal cancer is a common urologic malignancy, and therapeutic options for metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated with loss of von Hippel-Lindau tumor suppressor (pVHL) function and deregulation of hypoxia pathways.</abstracttext></p><h4>OBJECTIVE: </h4><p><abstracttext nlmcategory=”OBJECTIVE” label=”OBJECTIVE”>This review / Weiterlesen →

Long-term Outcome of Patients with Frequently Recurrent Non-muscle-invasive Bladder Carcinoma Treated with One Perioperative Plus Four Weekly Instillations of Mitomycin C Followed by Monthly Bacillus Calmette-Guérin (BCG) or Alternating BCG and Interferon

Long-term Outcome of Patients with Frequently Recurrent Non-muscle-invasive Bladder Carcinoma Treated with One Perioperative Plus Four Weekly Instillations of Mitomycin C Followed by Monthly Bacillus Calmette-Guérin (BCG) or Alternating BCG and Interferon

Eur Urol. 2015 Oct;68(4):611-7. doi: 10.1016/j.eururo.2015.02.022. Epub 2015 Mar 5.

Järvinen R, Marttila T, Kaasinen E, Rintala E, Aaltomaa S, Kallio J, Liukkonen T, Puolakka VM, Seppänen M, Tuhkanen K, Vaarala M, Viitanen J, Boström PJ; FinnBladder Group.

Department of Urology, Helsinki University Hospital, / Weiterlesen →

Prospective, Randomized, Multinational Study of Prostatic Urethral Lift Versus Transurethral Resection of the Prostate: 12-month Results from the BPH6 Study.

Prospective, Randomized, Multinational Study of Prostatic Urethral Lift Versus Transurethral Resection of the Prostate: 12-month Results from the BPH6 Study.

Eur Urol. 2015 Oct;68(4):643-52. doi: 10.1016/j.eururo.2015.04.024. Epub 2015 Apr 30.

Sønksen J, Barber NJ, Speakman MJ, Berges R, Wetterauer U, Greene D, Sievert KD, Chapple CR, Montorsi F, Patterson JM, Fahrenkrug L, Schoenthaler M, Gratzke C.

Department of Urology, Herlev Hospital, Herlev, Denmark.2Frimley Park / Weiterlesen →

Long-term Outcomes of the FinnBladder-4 Study.

Long-term Outcomes of the FinnBladder-4 Study.

Eur Urol. 2015 Oct;68(4):618-9. doi: 10.1016/j.eururo.2015.04.006. Epub 2015 Apr 15. No abstract available.

Svatek RS.

Department of Urology, Division of Urologic Oncology, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. Electronic address: Svatek@uthscsa.edu.

Eur Urol

ABSTRACT

Full Text Source: / Weiterlesen →

Everyday Cold Exposure and Urgency in Translation.

Everyday Cold Exposure and Urgency in Translation.

Eur Urol. 2015 Oct;68(4):662-3. doi: 10.1016/j.eururo.2015.04.011. Epub 2015 Apr 20. No abstract available.

Hedlund P.

Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden; Division of Oncology/Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy. / Weiterlesen →

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