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Scientific Knowledge Exchange on genitourinary cancers

In this Scientific Knowledge Exchange Prof. Dr. Manuela Schmidinger, Medical University of Vienna, and PD Dr. Richard Cathomas, Kantonsspital Graubünden in Chur, talk about the new data in genitourinary cancers.

Source: ASCO 2018

According to latest results, cytoreductive nephrectomy seems to be no longer a standard for certain patients in metastatic renal cell carcinoma, although some patient groups still benefit from surgery. In muscle invasive bladder cancer, neoadjuvant phase-II-results with immunotherapy show promising results.

The following abstracts are discussed in this SKE:

CARMENA: Cytoreductive nephrectomy followed by sunitinib versus sunitinib alone in metastatic renal cell carcinoma—Results of a phase III noninferiority trial.


Pembrolizumab monotherapy as first-line therapy in advanced clear cell renal cell carcinoma (accRCC): Results from cohort A of KEYNOTE-427.


A phase II study investigating the safety and efficacy of neoadjuvant atezolizumab in muscle invasive bladder cancer (ABACUS).


Preoperative pembrolizumab (pembro) before radical cystectomy (RC) for muscle-invasive urothelial bladder carcinoma (MIUC): Interim clinical and biomarker findings from the phase 2 PURE-01 study.