Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:275-9. doi: 10.1016/j.ejogrb.2014.08.010. Epub 2014 Aug 15.
Mandic-Markovic VD1, Mikovic ZM2, Djukic MK2, Vasiljevic MD2, Jankovic GLj3.
Author information 1School of Medicine, University of Belgrade, University Clinic for Gynecology and Obstetrics “Narodni front”, Belgrade, Serbia. Electronic address: email@example.comSchool of Medicine, University of Belgrade, University Clinic
Eur J Obstet Gynecol Reprod Biol
AbstractOBJECTIVE: Objective of our study was to evaluate changes in Doppler resistance indices in the common hepatic artery during normal pregnancy.STUDY DESIGN: Cross-sectional study included 210 healthy pregnant women gestational age 6-40 weeks, 40 healthy non-pregnant women and 30 women after delivery. We divided all pregnant women by pregnancy trimester. We registered pulsatility index (PI) and resistive index (RI) in the common hepatic artery and compared the evaluated values among non-pregnant women and women in first, second and third trimester and post partum and tested correlation of both parameters with gestational age. Statistical analysis was done by Chi square test, one-way ANOVA followed by post-hoc test and two-tailed Pearson and Spearman correlation. The difference was considered to be significant if p<0.05.RESULTS: We found lower values of PI and RI in the third trimester compared to control group and first and second trimester (p<0.01). There is negative correlation between the values of PI and RI with the gestation (p<0.01).CONCLUSION: Hepatic artery resistance indices decrease during the third trimester of pregnancy. This decrease may be the result of systemic arterial vasodilatation in normal pregnancy. The arterial resistance indices may be more useful for the evaluation of liver blood flow over the total blood flow as they are more reliable, being angle independent, easier to obtain, reflect vascular changes and might help in quick orientation about liver blood flow in pregnancies complicated by preeclampsia and HELLP syndrome. Our study is a pilot one, and further studies are needed to establish nomograms for the PI and RI during the gestation.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:25195201 | http://www.ncbi.nlm.nih.gov/pubmed/25195201