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Does Omegaven have beneficial effects on a rat model of ovarian ischemia/reperfusion?

Eur J Obstet Gynecol Reprod Biol. 2014 Oct;181:240-5. doi: 10.1016/j.ejogrb.2014.08.001. Epub 2014 Aug 13.

Gungor AN1, Turkon H2, Albayrak A3, Ovali M4, Islimye M5, Gencer M6, Hacivelioglu S6, Cevizci S7, Cesur I8, Cosar E6.
Author information 1Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Obstetrics and Gynecology, Canakkale, Turkey. Electronic address: dr_aysecakir@hotmail.com.2Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Bio
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
AbstractOBJECTIVE: The beneficial effects of omega-3 fatty acids on an intestinal ischemia/reperfusion (I/R) model was shown previously. Therefore, we aimed to examine the potential beneficial effects of parenteral omega-3 fatty acids, a safe and inexpensive product, on a rat model of ovarian I/R.STUDY DESIGN: A group of 39 rats was divided into six groups. Group 1 (Sham Group; n=6) underwent two laparotomies with a 3-h interval and their ovaries were removed 3h later. Group 2 (torsion-detorsion Group; n=7) had their ovaries torsioned clockwise and fixed at 720°; 3h later a detorsion operation was done and after another 3h, their ovaries were removed. Group 3 (n=7) and Group 4 (n=7) received the same treatment as Group 2; however, half an hour prior to detorsion, these rats received Omegaven at 1mL/kg and 5mL/kg, respectively. Group 5 (n=6) and Group 6 (n=6) received the same treatment as Group 1; however, half an hour prior to the second laparotomy, these rats received Omegaven at 1mL/kg and 5mL/kg, respectively. One ovary from each rat was evaluated histologically by hematoxylin and eosin (H&E) staining and the other ovary was homogenized and evaluated for total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI).RESULTS: While we failed to show any significant relationship among groups in oxidative parameters, there was a significant worsening in the torsion-detorsion group in histological evaluation. High Omegaven doses, but not low doses, improved tissue injury scores of torsioned and detorsioned ovaries to the levels observed in the control group.CONCLUSION: Omegaven improves the detrimental effects of ovarian I/R when used in sufficient doses. Its effects and dose adjustment on women with ovarian torsion must be investigated by further studies.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:25173683 | http://www.ncbi.nlm.nih.gov/pubmed/25173683

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