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CYP3A5 and ABCB1 Polymorphisms as Predictors for Sunitinib Outcome in Metastatic Renal Cell Carcinoma.

Eur Urol. 2015 Oct;68(4):621-9. doi: 10.1016/j.eururo.2015.04.018. Epub 2015 Apr 27.

Diekstra MH, Swen JJ, Boven E, Castellano D, Gelderblom H, Mathijssen RH, Rodríguez-Antona C, García-Donas J, Rini BI, Guchelaar HJ.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands; Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands.2Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands; Department of Medical Oncology, VU University Medical Centre, Amsterdam, The Netherlands.3Oncology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; Spanish Oncology Genitourinary Group (SOGUG), Madrid, Spain.4Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands; Department of Clinical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.5Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands; Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.6Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; ISCIII Centre for Biomedical Research on Rare Diseases (CIBERER), Madrid, Spain.7Spanish Oncology Genitourinary Group (SOGUG), Madrid, Spain; Oncology Unit, Clara Campal Comprehensive Cancer Centre, Madrid, Spain.8Department of Solid Tumour Oncology, Cleveland Clinic Foundation (CCF) Taussig Cancer Institute, Cleveland, OH, USA.9Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, The Netherlands; Dutch working group focusing on sunitinib-induced toxicity (SUTOX consortium), The Netherlands. Electronic address: H.J.Guchelaar@lumc.nl.

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