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Use of GnRH analogues pre-operatively for hysteroscopic resection of submucous fibroids: a systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177C:11-18. doi: 10.1016/j.ejogrb.2014.03.009. Epub 2014 Mar 15. Review.

Kamath MS1, Kalampokas EE2, Kalampokas TE3.
1Reproductive Medicine Unit, Christian Medical College, Vellore, 632004 India. Electronic address: dockamz@gmail.com.2Second Department of Obstetrics and Gynecology, Aretaieion” Hospital, University of Athens, Athens, Greece. Electronic address: m.kalampokas@gmail.com.3Division of Applied Health Sciences, University of Aberdeen, Aberdeen Maternity Hospital, Aberdeen, AB 25 ZL, UK. Electronic address: t.kalampokas@abdn.ac.uk.”
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
GnRH analogues are commonly used before hysteroscopic myomectomy to make surgery easier and safer, but they are expensive, have potential side effects and lack a robust evidence base to support this practice. We undertook a systematic review of the literature to determine whether, in women with submucous fibroids, pre-operative GnRH analogues were more effective than placebo/no treatment in terms of symptom relief, complications and ease of surgery. The outcomes were patient-reported relief of symptoms, complete resection of the fibroids, operative time and complications. Meta-analysis was performed where appropriate. Two trials including 86 women were identified. The assessment of symptom relief differed in the two trials: hence it was not possible to combine these data. The relative risk for completion of surgery and mean differences (95% confidence intervals) for operating time and fluid deficit were [0.94 (0.68-1.31); -5.34min, (-7.55min to -3.12min) and -176.2ml, (-281.05ml to -71.5ml)] respectively. Our results suggest that GnRHa may improve some outcomes but there is insufficient evidence to support their routine use prior to hysteroscopic resection of submucous fibroids. More randomised trials are needed to inform definitive conclusions.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:24702901 | http://www.ncbi.nlm.nih.gov/pubmed/24702901

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