Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:72-6. doi: 10.1016/j.ejogrb.2014.03.028. Epub 2014 Apr 8.
Igidbashian S1, Boveri S2, Radice D3, Casadio C4, Spolti N2, Sandri MT5, Sideri M2.
1Preventive Gynaecology Unit, European Institute of Oncology, via Ripamonti 435, 20141 Milano, Italy. Electronic address: firstname.lastname@example.orgPreventive Gynaecology Unit, European Institute of Oncology, via Ripamonti 435, 20141 Milano, Italy.3Division of Epidemiology and Biostatistics, European Institute of Oncology, via Ripamonti 435, 20141 Milano, Italy.4Diagnostic Cytology Unit, European Institute of Oncology, via Ripamonti 435, 20141 Milano, Italy.5Laboratory Medicine Division, European Institute of Oncology, via Ripamonti 435, 20141 Milano, Italy.
Eur J Obstet Gynecol Reprod Biol
OBJECTIVE: Strong evidences shows that HPV testing is more sensitive than cytology in detecting high-grade CIN. HPV test can be performed on samples collected by women themselves by means of self-sampling devices. This study compares the results of self-sampled HPV tests with the results of liquid based cytology (LBC).STUDY DESIGN: Seven hundred women scheduled for cervical cytology self-collected a cervicovaginal sample for HPV testing and then underwent a clinician-collected LBC at the European Institute of Oncology. The HPV and LBC results were compared with the McNemar test.RESULTS: All HSIL (N=5) resulted hrHPV positive. LBC resulted LSIL or worse in 38 (5.4%) women (out of 700). Self-sampled HPV was positive in 96 women (13.7%). A LSIL or worse LBC result was found in 15 (2.5%) patients, out of the 604 hrHPV negative women and in 23 (24%) patients, out of the 96 hrHPV positive women. Positive cytology after a self-sampled HPV positive result had an Odds Ratio of 12.4 (95% CI: 5.8-26.6).CONCLUSION: Self-collected HPV testing identifies a group of women at high risk of positive LBC and high grade SIL.Copyright © 2014. Published by Elsevier Ireland Ltd.
Full Text Source: Elsevier Science
PMID:24768230 | http://www.ncbi.nlm.nih.gov/pubmed/24768230