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Overt hypothyroidism is associated with the presence of uterine leiomyoma: a retrospective analysis.

Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:19-22. doi: 10.1016/j.ejogrb.2014.03.003. Epub 2014 Mar 13.

Ott J1, Kurz C1, Braun R1, Promberger R2, Seemann R3, Vytiska-Binstorfer E1, Walch K4.
1Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria.2Department of Surgery, Medical University of Vienna, Vienna, Austria.3Department of Craniomaxillofacial and Oral Surgery, Medical University of Vienna, Vienna, Austria.4Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Vienna, Vienna, Austria. Electronic address: katharina.walch@meduniwien.ac.at.
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
OBJECTIVE: A possible correlation between uterine leiomyoma and thyroid disease was reported decades ago. We aimed to evaluate the possible associations between the presence of uterine leiomyomas and (i) the presence of overt hypothyroidism, (ii) the level of anti-thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab), and (iii) thyroid stimulating hormone (TSH) levels.STUDY DESIGN: In a retrospective study, all 215 sterile women who underwent reproductive surgery (hysteroscopy and laparoscopy/laparotomy) at our department from January 2007 to January 2011 were included. All leiomyomas suspected on gynecologic ultrasound were verified during surgery. As risk factors for uterine leiomyomas, thyroid parameters, age, African heritage, age at menarche, parity, and body mass index were included.RESULTS: One or more uterine leiomyomas were found in 51 cases (23.7%). After multivariate analysis, three parameters remained significant, with African heritage the most important (odds ratio, OR, 27.80), followed by overt hypothyroidism (OR 3.10) and increasing age (OR 1.23). Larger leiomyomas were found in women with overt hypothyroidism than in those without overt hypothyroidism (median, 70mm; range, 5-88 vs. median, 30mm; range, 2-93, respectively; p=0.007).CONCLUSIONS: Overt hypothyroidism, but not autoantibodies against the thyroid gland, was associated with the presence of uterine leiomyoma in our study.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:24690197 | http://www.ncbi.nlm.nih.gov/pubmed/24690197

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