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Glassy cell carcinoma of the cervix: a literature review.

Eur J Obstet Gynecol Reprod Biol. 2014 Apr 13. doi:pii: S0301-2115(14)00188-2. 10.1016/j.ejogrb.2014.03.035. [Epub ahead of print] Review.

Zolciak-Siwinska A1, Jonska-Gmyrek J2.
1Department of Brachytherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland. Electronic address: agnieszka.zolciak@wp.pl.2Department of Radiotherapy, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
Glassy cell carcinoma (GCC) is a histologically aggressive subtype of cervical cancer with rapid growth and early metastases. The prognosis for patients with GCC is poor. This article reviews the literature pertinent to the epidemiology, cytology, pathology, immunohistochemistry, treatment and prognosis of GCC. MEDLINE (PubMed) was searched for all articles or abstracts on patients diagnosed with GCC published (in English) since the original definition by Glucksmann and Cherry, Cancer 1956;9:971. Accurate diagnosis of GCC enables implementation of the correct treatment strategy. Early-stage GCC should be treated with hysterectomy and pelvic lymph node dissection, with adjuvant radiochemotherapy if at least one intermediate or high risk factor for cervical cancer is present. Advanced GCC should be treated with neoadjuvant radiochemotherapy or chemotherapy with the aim of making the disease operable. There is a need for retrospective evaluation of GCC treatment from several centres to explore knowledge about this rare entity. Future studies should explore the role of targeted therapies and the most efficient chemotherapy regimen for the management of GCC.Copyright © 2014. Published by Elsevier Ireland Ltd.
Full Text Source: Elsevier Science
PMID:24792540 | http://www.ncbi.nlm.nih.gov/pubmed/24792540

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