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Effect of treatment of vitamin D deficiency and insufficiency during pregnancy on fetal growth indices and maternal weight gain: a randomized clinical trial.

Eur J Obstet Gynecol Reprod Biol. 2014 Jan;172:15-9. doi: 10.1016/j.ejogrb.2013.10.010. Epub 2013 Oct 19.

Hashemipour S1, Ziaee A1, Javadi A2, Movahed F2, Elmizadeh K2, Javadi EH2, Lalooha F3.
Author information 1Metabolic Diseases Research Center, Qazvin University of Medical Science, Qazvin, Iran.2Qazvin University of Medical Sciences, Qazvin, Iran.3Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: lalooha44@yahoo.com.
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
OBJECTIVE: To determine whether treatment of low serum vitamin D in pregnant women improves fetal growth indices.STUDY DESIGN: In this open-label randomized clinical trial, 130 Iranian pregnant women (24-26 weeks of gestation) with vitamin D deficiency or insufficiency [25(OH)D <30ng/ml] were divided at random into an intervention group and a control group. The control group received 200mg calcium plus a multivitamin (containing vitamin D3 400U) each day, and the intervention group received 200mg calcium plus a multivitamin (containing vitamin D3 400U) each day, plus vitamin D3 (50,000U) each week for 8 weeks. At delivery, maternal and cord blood 25(OH)D levels, maternal weight gain, neonatal length, neonatal weight and neonatal head circumference were compared between two groups. Serum vitamin D was measured using enzyme-linked immunosorbent assay. A multivariate regression analysis was performed to examine the independent effect of maternal vitamin D level on fetal growth indices.RESULTS: Mean (±standard deviation) length (intervention group: 49±1.6cm; control group: 48.2±1.7cm; p=0.001), head circumference (intervention group: 35.9±0.7cm; control group: 35.3±1.0cm; p=0.001) and weight (intervention group: 3429±351.9g; control group: 3258.8±328.2g; p=0.01) were higher in the intervention group compared with the control group. Mean maternal weight gain was higher in the intervention group compared with the control group (13.3±2.4kg vs 11.7±2.7kg; p=0.006). Multivariate regression analysis for maternal weight gain, neonatal length, neonatal weight and neonatal head circumference showed an independent correlation with maternal vitamin D level.CONCLUSION: Treatment of low serum vitamin D during pregnancy improves fetal growth indices and maternal weight gain.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:24210789 | http://www.ncbi.nlm.nih.gov/pubmed/24210789

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