Menü Logo medONLINE.at

Cytoreduction and HIPEC after neoadjuvant chemotherapy in stage IIIC-IV ovarian cancer. Critical analysis in elderly patients.

Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:88-93. doi: 10.1016/j.ejogrb.2014.05.018. Epub 2014 Jun 2.

Cascales-Campos P1, Gil J2, Gil E2, Feliciangeli E3, López V2, Gonzalez AG2, Ruiz-Pardo J2, Nieto A4, Parrilla P2.

Eur J Obstet Gynecol Reprod Biol
ABSTRACT
AbstractOBJECTIVES: The aim of our study was to evaluate postoperative morbidity and mortality, disease-free and overall survival in patients older than 75 years undergoing interval debulking after neoadjuvant chemotherapy and intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC).STUDY DESIGN: Were included a series of consecutive patients diagnosed with stages IIIC/IV ovarian carcinoma, intervened after neoadjuvant systemic chemotherapy (paclitaxel and carboplatin) between January 2008 and June 2013. After completion of cytoreduction HIPEC was administered using paclitaxel (60mg/m(2)) or cisplatin (75mg/m(2)). We analyzed and compared the results of postoperative morbidity and mortality, disease-free survival and overall survival in patients =75 years compared to patients with lower ages intervened in the same time period.RESULTS: From a total of 66 patients tested, 9 patients were =75 years (14%). Grade I-IV morbidity was significantly higher in patients =75 years (78% vs 35%, p<0.05) as well as grade III-IV disease (56% vs 16%, p<0.05). There were no procedure-related mortality. In patients =75 years the median disease-free survival was 6 months (95% CI: 3.5-8.5 months) vs 24 months (95% CI: 10.5-37.5 months) in younger patients. The median overall survival in patients =75 years was 13 months (95% CI: 4.7-21.3), not having reached at time of analysis of the database in younger patients.CONCLUSIONS: Patients =75 years received no benefit in prognosis after interval cytoreduction with HIPEC and paid a high price in terms of postoperative morbidity. This age group should be excluded from this therapeutic procedure.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:24965986 | http://www.ncbi.nlm.nih.gov/pubmed/24965986

Um den vollständigen Inhalt zu sehen, müssen Sie sich einloggen oder sich auf medONLINE.at registrieren.

Jetzt einloggen

Passwort vergessen

Jetzt kostenlos registrieren

Mit einer Anmeldung bei medONLINE.at haben Sie Zugriff auf: DFP-Kurse, Arzneimittelinfos, Produktfortbildungen und mehr.

Loggen Sie sich ein oder registrieren Sie Ihren kostenlosen medONLINE.at Account.