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Assisted reproductive technology (ART) treatment in women with schizophrenia or related psychotic disorder: a national cohort study.

Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:115-20. doi: 10.1016/j.ejogrb.2014.03.013. Epub 2014 Mar 15.

Ebdrup NH1, Assens M2, Hougaard CO2, Pinborg A3, Hageman I4, Schmidt L2.
1Department of Public Health, University of Copenhagen, 5 Øster Farimagsgade, P.O. Box 2099, DK-1014 Copenhagen K, Denmark. Electronic address: nebdrup@gmail.com.2Department of Public Health, University of Copenhagen, 5 Øster Farimagsgade, P.O. Box 2099, DK-1014 Copenhagen K, Denmark.3Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre Hospital, 30 Kettegårds Allé, DK-2650 Hvidovre, Denmark.4Psychiatric Center Copenhagen, Copenhagen University Hospital, Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen Ø, Denmark.
Eur J Obstet Gynecol Reprod Biol
ABSTRACT
OBJECTIVES: To determine the prevalence rate of women with a diagnosis of schizophrenia or related psychotic disorder in assisted reproductive technology (ART) treatment and to study these women’s fertility treatment outcome in comparison to women with no psychotic disorders.STUDY DESIGN: We used a national register-based cohort of 42,915 Danish women in ART treatment from 1.1.1994 to 30.9.2009. All women with a diagnosis of schizophrenia or related psychotic disorders before, during or after their ART treatment were identified by individual-level linkage of nationwide registers of ART treatment, psychiatric admission, birth and socio-demographic status. The comparison group (N=42,671) consisted of all women in the study cohort never diagnosed with psychotic disorders. Conventional descriptive methods were used for the statistical analyses.RESULTS: Two hundred and forty-four (0.6%) women in the study cohort received a diagnosis of psychotic disorder before (N=135-55.3%), during (N=7-2.9%) or after (N=102-41.8%) ART treatment. The mean time from last diagnosis of psychotic disorder to their first ART treatment in the 135 women with a psychiatric diagnosis prior to their first ART treatment was 7.1±5.6 years (25-75% percentile: ±2.8-10.4 years). The most frequent diagnoses were acute and transient psychotic disorder. Women with a diagnosis of schizophrenia or related psychotic disorder before their first ART treatment had a lower ART treatment success rate as significantly fewer women obtained a live birth (40.0% vs. 51.9%, P<0.01). However, we found no statistical differences in perinatal outcomes for the children born by women in the study population and comparison group.CONCLUSIONS: The prevalence of women with a psychotic diagnosis in fertility treatment is lower than the prevalence in the general population. Women with a psychotic disorder prior to ART treatment have a lower fertility treatment success rate compared to women without psychotic disorder. Women with a psychotic disorder achieving delivery show similar obstetric outcomes to women with no psychotic disorder.Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Full Text Source: Elsevier Science
PMID:24721442 | http://www.ncbi.nlm.nih.gov/pubmed/24721442

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