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Anti-Müllerian hormone, testosterone and free androgen index following the dose-adjusted unilateral diathermy in women with polycystic ovary syndrome.

Eur J Obstet Gynecol Reprod Biol. 2014 Aug;179:163-9. doi: 10.1016/j.ejogrb.2014.05.011. Epub 2014 Jun 2.

Sunj M1, Canic T2, Jeroncic A3, Karelovic D4, Tandara M1, Juric S3, Palada I1.

Eur J Obstet Gynecol Reprod Biol
ABSTRACT
AbstractOBJECTIVE: The aim of this study was to investigate changes of anti-Müllerian hormone, testosterone and free androgen index after two diathermy methods. We have also aimed at evaluating prognostic value of these parameters for an ovulatory response.STUDY DESIGN: This prospective, comparative study included ninety-six women with polycystic ovary syndrome unresponsive to clomiphene citrate. Patients were assigned to two groups; the first group underwent unilateral laparoscopic ovarian drilling with thermal doses adjusted to ovarian volume: median of 720J (IQR), while the second group underwent bilateral drilling with fixed doses of 1200J. Anti-Müllerian hormone (AMH), testosterone (T), free androgen index (FAI)and luteinizing hormone (LH) were measured at baseline, at 1st and 6th month of follow up.RESULTS: AMH, T and LH levels significantly decreased (P<0.001, P=0.024, P<0.001) after diathermy in both responders and nonresponders from either treatment group. On contrary, FAI levels (P<0.001) significantly changed only in responders, irrespective of the treatment. In 1st and 6th month of follow up median levels of AMH, T and FAI among responders from different treatment groups were equivalent, whereas the responders in bilateral group had higher LH levels in the 1st month of follow up (P=0.003). Nonresponders differed between treatment groups only in AMH level which was decreased in unilateral group throughout the follow up (P=0.021). The baseline value of T (semi-standardized coefficient, ß=-0.28) and value of T in the 1st month (ß=-0.72) after the diathermy were significant and consistent indicator of the response to therapy within 6months and the ovulation response in the 1st month.CONCLUSIONS: The value of T is the strongest and consistent indicator of ovulatory response after diathermy.CLINICAL TRIAL REGISTRATION: www.ClinicalTrials.gov , NCT01833949.Copyright © 2014. Published by Elsevier Ireland Ltd.
Full Text Source: Elsevier Science
PMID:24965999 | http://www.ncbi.nlm.nih.gov/pubmed/24965999

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